Project information
Structure-functional Relationships of Haloalkane Dehalogenases
- Project Identification
- GAP207/12/0775
- Project Period
- 1/2012 - 12/2016
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Science
- Cooperating Organization
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University of South Bohemia České Budějovice
Proposed project is continuation of a very productive cooperation between the Institute of Physical Biology University of South Bohemia and the Loschmidt Laboratories at Masaryk University. This cooperation has started in 2006 within the project of Centre for Biocatalysis and Biotransformation LC06010 supported by the Czech Ministry of Education. This project has yielded 7 joint impacted publications and more than 30 conference contributions during the past 6 years. Moreover, 5 Ph.D. theses will be finished during 2010-2013. To keep high standard for this running collaboration, we would like to continue with the research project in the framework of GACR project named “Structure-Functional Relationships of Haloalkane Dehalogenases“.
Publications
Total number of publications: 23
2017
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Kinetics of Binding of Fluorescent Ligands to Enzymes with Engineered Access Tunnels
FEBS Journal, year: 2017, volume: 284, edition: 1, DOI
2016
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Engineering a de Novo Transport Tunnel
ACS Catalysis, year: 2016, volume: 6, edition: 11, DOI
2015
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Balancing the Stability-Activity Trade-off by Fine-Tuning Dehalogenase Access Tunnels.
ChemCatChem, year: 2015, volume: 7, edition: 4, DOI
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Instability restricts signaling of multiple fibroblast growth factors
Cellular and Molecular Life Sciences, year: 2015, volume: 72, edition: 12, DOI
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Site-specific Analysis of Protein Hydration Based on Unnatural Amino Acid Fluorescence.
Journal of the American Chemical Society, year: 2015, volume: 137, edition: 15, DOI
2014
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Comparison of Catalysis by Haloalkane Dehalogenases in Aqueous Solutions of a Deep Eutectic and Organic Solvents.
Green Chemistry, year: 2014, volume: 16, edition: 5, DOI
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Crystallographic Analysis of 1,2,3–Trichloropropane Biodegradation by Haloalkane Dehalogenase DhaA31
Acta Crystallographica D, year: 2014, volume: 70, edition: february, DOI
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Microscopic Monitoring Provides Information on Structure and Properties During Biocatalyst Immobilisation.
Biotechnology Journal, year: 2014, volume: 9, edition: 6, DOI
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Structural and Functional Analysis of a Novel Haloalkane Dehalogenase with Two Halide-Binding Sites.
Acta Crystallographica D, year: 2014, volume: 70, edition: July, DOI
2013
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Are Time-Dependent Fluorescence Shifts at the Tunnel Mouth of Haloalkane Dehalogenase Enzymes Dependent on the Choice of the Chromophore?
Journal of Physical Chemistry B, year: 2013, volume: 117, edition: 26, DOI