Project information
Bezpečná biotechnologie alotransplatovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie (NPVII11001)

Information

This project doesn't include Faculty of Science. It includes Faculty of Medicine. Official project website can be found on muni.cz.

Project Identification

2B06058

Project Period

7/2006 - 6/2011

Investor / Pogramme / Project type

Ministry of Education, Youth and Sports of the CR

Health and quality of life

MU Faculty or unit

Faculty of Medicine

prof. MUDr. Jaroslav Michálek, Ph.D.
prof. MUDr. Roman Hájek, CSc.
RNDr. Libor Hanák, Ph.D.
RNDr. Radek Horváth, Ph.D.
Dana Hrušková
Mgr. Veronika Janečková, Ph.D.
RNDr. Jiří Jelínek, Ph.D.
RNDr. Eva Matějková
Mgr. Klára Mollová
Mgr. Lucie Říhová, Ph.D.
Mgr. Jana Smejkalová, Ph.D.
doc. RNDr. Sabina Ševčíková, Ph.D.
Mgr. Hana Šváchová, Ph.D.
Petra Vidláková
Mgr. Kateřina Vopěnková, Ph.D.

Cooperating Organization

Genex CZ, s.r.o.

Safe biotechnology of allotransplated hematopoietic stem cells in selected solid and haematologic tumors as an adoptive immunotherapy

The project focuses on the adoptive immunotherapy using experimental allogeneic hematopoietic stem cell transplantation. It primarily concentrates on finding a safe biotechnology of allogeneic stem cell graft preparation to minimize its unwanted alloreactivity leading often to lethal graft-versus-host reaction, and at the same time to preserve and potentiate its anti-tumor reactivity. Experimental verification of this procedure could lead to a rapid progress in the clinical usage of allogeneic transplantation in oncology and other fields.

Results

Publications

Total number of publications: 82

2011

VYUŽITÍ MOLEKULÁRNÍ BIOLOGIE V DIAGNOSTICE A LÉČBĚ DĚTSKÝCH ONEMOCNĚNÍ

MICHÁLEK Jaroslav

Conference abstract

Year: 2011, type: Conference abstract

2010

Aktivace CMV-specifických CD8+ T lymfocytů pomocí adenylátcyklázového toxoidu nesoucího epitopy odvozené od CMV proteinu pp65

JELÍNEK Jiří ADKINS Irena ŠEBO Petr MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Comparison of five currently used DC maturation strategies and their influence on DC characteristics

SKÁLOVÁ Kateřina MOLLOVÁ Klára BUREŠOVÁ Ivana MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Expanze T lymfocytů pro adoptivní transfer z mononukleárních buněk periferní krve za využití přístroje WAVW Bioreactor

VIDLÁKOVÁ Petra KORDAČOVÁ Lucie CIBULKA Marek SMEJKALOVÁ Jana MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Human myeloid dendritic cells for cancer therapy: does maturation matter?

SKÁLOVÁ Kateřina MOLLOVÁ Klára MICHÁLEK Jaroslav

Article in Periodical

Vaccine, year: 2010, volume: 28, edition: 32
In vitro activation of CMV-specific human CD8+ T cells by CyaA toxoids delivering pp65 epitopes

JELÍNEK Jiří ADKINS Irena ŠEBO P. MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
In vitro activation of CMV-specific T-cell response using CyaA toxoids delivering peptide antigenic epitopes derived from pp65 protein

JELÍNEK Jiří ADKINS I. ŠEBO P. MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma

MICHÁLEK Jaroslav OČADLÍKOVÁ Darina MATĚJKOVÁ Eva FOLTÁNKOVÁ Veronika DUDOVÁ Silvie SLABÝ Ondřej HORVÁTH Radek POUR Luděk HÁJEK Roman

Article in Periodical

British Journal of Haematology, year: 2010, volume: 148, edition: 6
Manufacturing of bone marrow-derived mesenchymal stromal cells according to GMP requirements for clinical trials

FOLTÁNKOVÁ Veronika KOLÁČNÁ Kateřina MATĚJKOVÁ Eva SMEJKALOVÁ Jana MICHÁLEK Jaroslav

Conference abstract

Year: 2010, type: Conference abstract
Mesenchymal stem cells: from lab to clinical trials in Crohn's disease

LATA Jan MICHÁLEK Jaroslav FOLTÁNKOVÁ Veronika KOLÁČNÁ Kateřina

Conference abstract

Year: 2010, type: Conference abstract