Project information
Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
- Project Identification
- MSM0021622430
- Project Period
- 1/2007 - 12/2013
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Faculty of Medicine
- Other MU Faculty/Unit
- Faculty of Science
- Other MU Faculty/Unit
- Faculty of Informatics
- Other MU Faculty/Unit
- Central European Institute of Technology
- Keywords
- embryonic stem cells
The goal of this project will be a) to profit from availability of unique cellular resources - mouse and human embryonic stem cells and normal and malignant hematopoietic stem/progenitor cells, b) to effectively employ a wide variety of current and complementary methodologies available to the consortium, and c) to exploit a proven/certified expertise in working with various living systems that span from in vitro cultured cells, through animal models to oncohematological patients. All this together will represent a powerful experimental platform aimed at addressing a nature of molecules and molecular mechanisms underlaying phenomena that are common to both normal and cancer stem cells, mainly their ability to self-renew and to enter differentiation pathways. Integral part of this general goal is to implement multifaceted analytical approach that will cover studies of gene expression at both mRNA and protein levels, evaluating function of extra and intracellular signaling pathways, and analyzing biological properties of cells in vitro and in vivo. Expected outcome will be not only understanding but also a definition of molecules and/or molecular pathways to be tested as therapeutic targets, and cellular models that will make such testing feasible.
Publications
Total number of publications: 357
2009
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Monitoring of minimal residual disease in NPM1 mutated acute myeloid leukemia (AML) – a single center experience in 27 patients.
Blood, year: 2009, volume: 114
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Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival, and response to DNA damage.
Blood, year: 2009, volume: 114/2009, edition: 26
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New prognostic markers of chronic lymphocytic leukemia in the everyday hematological practice. A multicenter analysis.
Haematologica - the hematology journal, year: 2009, volume: 94, edition: Suppl. 2
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Nové prognostické faktory chronické lymfocytární leukemie (CLL) v každodenní hematologické praxi Multicentrická analýza.
Year: 2009, type: Conference abstract
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p53 inactivation and genomic abberations in chronic myeloid leukemia
Year: 2009, type: Conference abstract
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Proteomická analýza nádorových buněk
Klinická onkologie, year: 2009, volume: 22, edition: 5
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Representation of T-cell receptor V beta families detected by reverse transcription PCR and capillary electrophoresis
Experimental Hematology, Volume 37, Number 9, year: 2009
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Sekvenování lidského genomu - technologie nové generace aneb budeme rutinně sekvenovat lidské genomy?
Časopis lékařů českých, year: 2009, volume: 148, edition: 7
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Stanovení minimální zbytkové nemoci u B-buněčné chronické lymfocytární leukemie: možnosti a vývoj metodických přístupů založených na PCR a RQ-PCR
Transfuze a hematologie dnes, year: 2009, volume: 15, edition: 4
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Successful treatment of steroid-refractory hepatitic variant of liver graft-vs-host disease with pulse cyclophosphamide
Experimental Hematology, year: 2009, volume: 37, edition: 6, DOI