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Project information
An integrative strategy of testing systems for identification of EDs related to metabolic disorders (OBERON)

Investor logo
Project Identification
825712
Project Period
1/2019 - 6/2024
Investor / Pogramme / Project type
European Union
  • Horizon 2020
  • Health, demographic change and wellbeing (Societal Challenges)
MU Faculty or unit
Faculty of Science
Cooperating Organization
Institute of Biophysics
Inserm Transfert
Institut national de la santé et de la recherche médicale
  • Responsible person Dr. Karine Audouze
Di Mario Negri Institute for Pharmacological Research
Barcelona Institute for Global Health
ARISTOTLE UNIVERSITY OF THESSALONIKI
ANSES
Miguel Hernández University
Institut national de l'environnement industriel et des risques
Metabolon GmbH

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism.
Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the
second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No. 3 – Good health and well-being Sustainable Development Goal No. 12 – Responsible consumption and production Sustainable Development Goal No. 16 – Peace, justice and strong institutions Sustainable Development Goal No. 17 – Partnerships for the goals

Publications

Total number of publications: 6

2024

2023

  • ELIXIR and Toxicology: a community in development [version 2; peer review: 2 approved]

    MARTENS Marvin STIERUM Rob SCHYMANSKI Emma L. EVELO Chris T. AALIZADEH Reza ALADJOV Hristo ARTURI Kasia AUDOUZE Karine BABICA Pavel BERKA Karel BESSEMS Jos BLÁHA Luděk BOLTON Evan E. CASES Montserrat DAMALAS Dimitrios ?. DAVE Kirtan DILGER Marco EXNER Thomas GEERKE Daan P. GRAFSTRÖM Roland GRAY Alasdair HANCOCK John M. HOLLERT Henner JELIAZKOVA Nina JENNEN Danyel JOURDAN Fabien KAHLEM Pascal KLÁNOVÁ Jana KLEINJANS Jos KONDIC Todor KONE Boi LYNCH Iseult MARAN Uko CUESTA Sergio Martinez MÉNAGER Hervé NEUMANN Steffen NYMARK Penny OBERACHER Herbert RAMIREZ Noelia REMY Sylvie ROCCA-SERRA Philippe SALEK Reza M. SALLACH Brett SANSONE Susanna-Assunta SANZ Ferran SARIMVEIS Haralambos SARNTIVIJAI Sirarat SCHULZE Tobias SLOBODNIK Jaroslav SPJUTH Ola TEDDS Jonathan THOMAIDIS Nikolaos WEBER Ralf J.M. VAN WESTEN Gerard J.P. WHEELOCK Craig E. WILLIAMS Antony J. WITTERS Hilda ZDRAZIL Barbara ŽUPANIČ Anže

    Article in Periodical

    F1000Research, year: 2023, volume: 10, DOI

2022

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