Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2005
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Allium cepa possess proteins able to bind the human- and Arabidopsis-type of telomeric sequence
Year: 2005, type: Conference abstract
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Analysis of histopathologic and molecular genetic findings in Czech LGMD2A patients
Neuromuscular disorders, year: 2005
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Analysis of histopathologic and molecular pathologic findings in Czech LGMD2A patients.
Muscle Nerve, year: 2005, volume: 33, edition: 3
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Analysis of plant telomere-binding proteins
The FEBS Journal, year: 2005
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Analysis of SMN gene regions in patients with spinal muscular atrophy
Functional genomics and disease, year: 2005
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Analýza genomu a proteomu polyvalentního stafylokokového bakteriofága 812
Informační listy Česko-Slovenské genetické společnosti Gregora Mendela., year: 2005, volume: 28, edition: 1
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Analýza proteomu polyvalentního fága
Študentská vedecká konferencia, year: 2005
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Analyzátory doby letu (TOF), QqTOF a TOF/TOF
Year: 2005, number of pages: 1 s.
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Antiproliferative activities of selected benzo[c]phenanthridine alkaloids.
Biomedical Papers, year: 2005
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Application of PCR, rep-PCR and RAPD techniques for typing of Lactococcus lactis strains
Folia Microbiologica, year: 2005, volume: 50, edition: 2