Project information
Molecular basis of cell and tissue regulations
- Project Identification
- MSM0021622415
- Project Period
- 1/2005 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Research Intents
- MU Faculty or unit
- Central European Institute of Technology
- Other MU Faculty/Unit
- Faculty of Medicine
- Keywords
- Cell; genomics; proteomics; biomedicine; gene expression; regulation mechanisms; chromatin structure; structure and interactions of biomolecules
The cell is a system in which each molecule is a component of interaction network. Due to the highly complex interconnection, function of cells and organisms is relatively resistant to failure of individual components of the network. Convergence of thought and methodical approaches which is characteristic for today’s postgenomic era, is a basis for interconnection of research capacities of molecular-biology oriented workgroups of the Masaryk University in the proposed Research Plan (RP). Solving of the RP will proceed in 4 program areas: 1. Regulation mechanisms in animal cells; 2. Functional domains of eukaryotic chromosomes; 3. Genomics and proteomics of regulation circuits in plants; 4. Functional analysis of the genome of clinically and biotechnologically important bacteria. The RP objective is to use approaches of structural biology, functional genomics, proteomics and bioinformatics to elucidate molecular basis of processes which are important from the viewpoint of perspective biomedical and biotechnology applications.
Publications
Total number of publications: 1210
2005
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Telomeres in evolution and evolution of telomeres
Chromosome Research, year: 2005, volume: 13, edition: 5
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The presence of spirochetes in arthropods parasiting small rodents focused on the pathogenic Borrelia burgdorfei sensu lato
Year: 2005, type: Conference abstract
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THE ROLE OF VIMENTIN EXPRESSION IN MONOCYTE/MACROPHAGE DIFFERENTIATION
XIII. Cytoskeletální Klub, year: 2005
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The yield of chromosomal aberrations in children with acute leukemia using methods GTG banding, FISH, CGH and HR-CGH
European Journal of Human Genetics, year: 2005
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Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts
Sborník příspěvků IX. pracovního setkání biochemiků a molekulárních biologů, year: 2005
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Versatility of proteome during terminal differentiation of v-myb-transformed monoblasts
Študentská vedecká konferencia, year: 2005
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Využití průtokové cytometrie pro identifikaci mezidruhových hybridů rodu Trifolium
Zborník z 12. odborného seminára "Nové poznatky z genetiky a šľachtenia poľnohospodárských rastlín", Výskumný ústav rastlinnej výroby Piešťany, 23.-24. november 2005, year: 2005
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Využití průtokové cytometrie pro sledování proliferace a diferenciace monoblastů transformovaných onkogenem v-myb
Analytická cytometrie III, year: 2005
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X-linked Charcot-Marie-Tooth disease: phenotypic expression of a novel mutation Ile127Ser in the GJB1 (connexin 32) gene
Muscle Nerve, year: 2005, volume: 31, edition: 2
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Zjišťování výskytu spirochet u členovců parazitujících u drobných hlodavců zaměřené na patogenní Borrelia burgdorferi sensu lato
Year: 2005, type: Conference abstract